Synthesis and Anticancer Evaluation of Some New 3-Benzyl-4,8-Dimethylbenzopyrone Derivatives



Sohair L. El-Ansary1, 2, Doaa E. Abdel Rahman1, Lina M. A. Abdel Ghany2, *
1 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo 11562, Egypt
2 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Misr University for Science and Technology, Misr, Egypt


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© 2017 El-Ansary et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this authors at the Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Misr University For Science and Technology, Al-Motamayez District, P.O.Box: 77, Misr, Egypt; Tel: +202- 38247455, 38247456, 38247457; E-mails: dr.linaamin@gmail.com, lina.amin@must.edu.eg


Abstract

Introduction:

New benzopyrone derivatives such as Schiff’s like compounds, acetohydrazides or substituted with oxadiazole or pyrazole heterocycles were synthesized from parent acid hydrazide compound 3.

Methods and Materials:

Structures of the synthesized compounds were elucidated using IR, NMR and mass spectroscopy. All the synthesized derivatives were selected by National Cancer Institute (NCI), Bethesda, and evaluated for their in vitro anticancer activity in the full NCI 60 cell lines panel assay.

Results and Conclusion:

Schiffs like compounds 4a, b and c were found to have good growth inhibition % against numerous cell lines that belong mainly to leukemia, non-small cell lung, CNS and breast Cancer subpanels.

Keywords: Benzopyrones, Acid hydrazide, Oxadiazoles, Pyrazoles, Anticancer.