Aims and Scope
Role of Glucagon-like Peptide-1 (GLP-1) Agonists in the Management of Diabetic Patients with or without COVID-19Fatemeh Mirzaei, Iraj Khodadadi, Nesrine Majdoub, Seyyed Alireza Vafaei, Heidar Tayebinia and Ebrahim Abbasi
The Open Medicinal Chemistry Journal, 2022; 16: e187410452212130.
Electronic Publication Date: December 21, 2022
A Review on The Medicinal And Industrial Applications of N-Containing HeterocyclesAndleeb Amin, Tanzeela Qadir, Praveen Kumar Sharma, Ishtiaq Jeelani and Hitoshi Abe
The Open Medicinal Chemistry Journal, 2022; 16: e187410452209010.
Electronic Publication Date: November 16, 2022
Synthesis and Evaluation of New Derivatives of Busulfan as an Anti-carcinogenic Drug against k562 Cancer Cells Using the AO / PI MethodHadi Jabbari, Setareh Khosravi and Saeid Azimi
The Open Medicinal Chemistry Journal, 2022; 16: e187410452209140.
Electronic Publication Date: October 28, 2022
HPLC and HPLC-MS Analysis of Intestinal Elimination and Phase 2 Metabolism of 4'-hydroxy-4-Methoxychalcone and its Bis-Mannich Analog In The RatAline Bernardes, Mónika Kuzma, Attila Almási, Mátyás Mayer, Caridad Noda Pérez and Pál Perjési
The Open Medicinal Chemistry Journal, 2022; 16: e187410452208110.
Electronic Publication Date: October 17, 2022
Biological Evaluation and Reverse Pharmacophore Mapping of Innovative Bis-Triazoles as Promising Anticancer AgentsMaysaa M. Saleh, Amjad N. Abuirmeileh, Rabaa M. Al-Rousan, Suha M. Abudoleh, Loay K. Hassouneh, Malek A. Zihlif, Mutasem O. Taha, Reem F. Abutayeh, Hebah Mansour and Bashaer Abu-Irmaileh
The Open Medicinal Chemistry Journal, 2022; 16: e187410452207200.
Electronic Publication Date: September 19, 2022
Antiviral Activity of Benzotriazole Based DerivativesPaola Corona, Sandra Piras, Roberta Ibba, Federico Riu, Gabriele Murineddu, Giuseppina Sanna, Silvia Madeddu, Ilenia Delogu, Roberta Loddo, Antonio Carta
For the last thirty years, the benzotriazole scaffold has been the object of our group interest and we have already presented some results on the antiviral activity of our compounds.
In this article, we conclude the exploration of N-(4-(R-2H-benzo[d][1,2,3]triazol-2-yl)phenyl)-4-R’-benzamides and 1-(4-(R-2H-benzo[d][1,2,3]triazol-2-yl)phenyl)-3-R’-ureas by synthesizing further modified derivatives, in order to have more elements for SARs evaluation.
Here, we reported the synthesis and the antiviral screening results of 38 newly synthesized benzotriazole derivatives against a panel of DNA and RNA viruses. We also analyse SARs in comparing these compounds with previously published benzotriazole analogues, taking stock of the situation.
Among the newly presented derivatives, compounds 17 and 18 were the most active with EC50 6.9 and 5.5 µM, respectively against Coxsackievirus B5 (CV-B5) and 20.5 and 17.5 µM against Poliovirus (Sb-1).
we can conclude that N-(4-(2H-benzo[d] [1 - 3] triazol-2-yl)phenyl-R-amide is a good chemical scaffold for the development of new antiviral molecules.
October 23, 2020