REVIEW ARTICLE

Synthesis of Medicinally Important Indole Derivatives: A Review

The Open Medicinal Chemistry Journal 30 Sept 2021 REVIEW ARTICLE DOI: 10.2174/1874104502015010001

Abstract

Indoles constitute a widely occurring functional group in nature and are present in an extensive number of bioactive natural products and medicinally important compounds. As a result, exponential increases in the development of novel methods for the formation of indole core along with site-specific indoles have been established. Conventional methods for the synthesis of indoles are getting replaced with green methods involving ionic liquids, water as a solvent, solid acid catalyst, microwave irradiation and the use of nanoparticles under solvent-free conditions. In addition, there are immense applications of the substituted indoles in diverse fields.

Keywords: Indoles, Ionic liquids, Microwave irradiation, Nanoparticles, Heterocyclic compounds, Anti-tubercular.
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