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One-pot Synthesis of Chemical Delivery Systems for Gamma-aminobutyric Acid and its Analogues
Roman Zavadovskiy1
Anna Polivanova1
Kenul Abbasova2
Elena Shipulo1
Authors Info & Affiliations
Abstract
Introduction:
A one-pot synthesis route was proposed for the synthesis of chemical delivery systems of bifunctional compounds containing carboxylic- and amino groups, such as gamma-aminobutyric acid and its structural analogues, gabapentin and phenibut.
Methods:
To obtain targeted compounds, consecutive esterification, amidation, methylation, and reduction were employed in contrast to a more traditional approach that requires isolation and purification of semi-products after each reaction step.
Results:
A significant (nearly two-fold) increase in yields was observed when target compounds were synthesized using a one-pot approach compared to the conventional one.
Conclusion:
One-pot approach is a possible and beneficial way for the synthesis of chemical delivery systems for gabapentinoids and other drugs containing carboxylic and amino groups.
