One-pot Synthesis of Chemical Delivery Systems for Gamma-aminobutyric Acid and its Analogues
Aleksey Semyonkin1, *, Roman Zavadovskiy1, Anna Polivanova1, Kenul Abbasova2, Elena Shipulo1
Identifiers and Pagination:Year: 2023
E-location ID: e187410452304120
Publisher ID: e187410452304120
Article History:Received Date: 17/01/2023
Revision Received Date: 08/03/2023
Acceptance Date: 24/03/2023
Electronic publication date: 17/05/2023
Collection year: 2023
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
A one-pot synthesis route was proposed for the synthesis of chemical delivery systems of bifunctional compounds containing carboxylic- and amino groups, such as gamma-aminobutyric acid and its structural analogues, gabapentin and phenibut.
To obtain targeted compounds, consecutive esterification, amidation, methylation, and reduction were employed in contrast to a more traditional approach that requires isolation and purification of semi-products after each reaction step.
A significant (nearly two-fold) increase in yields was observed when target compounds were synthesized using a one-pot approach compared to the conventional one.
One-pot approach is a possible and beneficial way for the synthesis of chemical delivery systems for gabapentinoids and other drugs containing carboxylic and amino groups.