Molecular Insights into Oxidative Stress and Its Clinical Implications

Abstract

Oxidative stress plays a crucial role in the pathophysiology of numerous diseases, including cardiovascular disorders, diabetes, neurodegenerative conditions, and chronic kidney disease. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are key contributors to cellular damage through oxidative and nitrosative stress, affecting cellular processes such as apoptosis, inflammation, and fibrosis. This review explores the molecular mechanisms underlying oxidative stress, its connection to various diseases, and the role of enzymatic and non-enzymatic antioxidants in counteracting its harmful effects. Emerging therapeutic strategies, such as Nrf2 activators and mitochondria-targeted antioxidants, are highlighted as promising tools for disease prevention and treatment. Understanding the interplay between oxidative stress and disease progression can pave the way for precision medicine approaches, offering more personalized and effective treatments.