Important Bioactive Molecules of Erythrocytes in Colorectal Cancer Patients After Colectomy



Anna Blázovics*, 1, Ágnes Szilvás2, György Székely2, Enikő Tordai3, Edit Székely4, Gábor Czabai5, Zsolt Pallai5, Éva Sárdi3
1 II. Department of Medicine, Semmelweis University, Budapest
2 Saint John Hospital, Budapest, Hungary
3 Department of Genetics and Plant Breeding, Corvinus University of Budapest, Budapest, Hungary
4 Central Hospital of the Hungarian State Railways, Budapest, Hungary
5 Diachem Ltd., Budapest, Hungary


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open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.

* Address correspondence to this author at the II. Department of Medicine, Semmelweis University, H-1088, Szentkirályi St. 46. Budapest, Hungary; E-mail: blaz@bel2.sote.hu


Abstract

Formaldehyde (HCHO) and protoporphyrin, are in connection with redox homeostasis. Data show the importance of HCHO in proliferative as well as in apoptotic processes. Free protoporphyrin can be detected near the Zn-protoporphyrin in cancer and it has pro- and antioxidant forms depending on concentrations. The aim was to determine the amount of HCHO and protoporphyrin concentrations of erythrocytes in colorectal cancer after colectomy and to estimate redox homeostasis. Total 32 adult patients after 5-10 years of colectomy and 9 healthy volunteers were drawn into this study. Tumor markers, redox parameters, HbA1c, HCHO and protoporphyrin concentrations were measured. Erytrocyte HCHO was significantly lower in colectomysed patients, than in controls. Protoporphyrin concentration was low in patients, but in metastasis its concentration was significant. HbA1c correlated significantly with free radicals and decreased the antioxidant status of erythrocytes. HCHO and protoporphyrin concentrations of erythrocytes and the total scavenger capacity are very important indexes in cancer

Keywords: Colorectal cancer, HCHO, protoporphyrin, redox homeostasis.