The Investigation of Structure-Activity Relationships of Tacrine Analogues: Electronic-Topological Method

Murat Saracoglu*, 1, Fatma Kandemirli2
1 Faculty of Education, Erciyes University, 38039, Kayseri, Turkey
2 Department of Chemistry, Kocaeli University, 41000, Izmit, Turkey

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© Saracoglu and Kandemirli; Licensee Bentham Open

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.

* Address correspondence to this author at the Faculty of Education, Erciyes University, 38039, Kayseri, Turkey Tel: +90-352-4374901; Fax: +90-352-4378834;


In this study we investigated the structure-activity relationships by using the Electron- Topological Method (ETM) for a class of AChE inhibitors related to tacrine (9-amino-1,2,3,4-tetrahydroacridine) and 11 H-Indeno-[1,2-b]-quinolin-10-ylamine that tetracyclic tacrine analogues, a drug currently in use for the treatment of the AD. Molecular fragments being specific for active and inactive compounds were revealed by using ETM. The result of testing showed the high ability of ETM in predicting the activity and inactivity in investigated series.

Keywords: Tacrine analogues, AChE, structure-activity relationships, electronic-topological method.