The Investigation of Structure-Activity Relationships of Tacrine Analogues: Electronic-Topological Method
Murat Saracoglu*, 1, Fatma Kandemirli2
Identifiers and Pagination:Year: 2008
First Page: 75
Last Page: 80
Publisher ID: TOMCJ-2-75
Article History:Received Date: 17/6/2008
Revision Received Date: 14/7/2008
Acceptance Date: 15/7/2008
Electronic publication date: 6/8/2008
Collection year: 2008
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
In this study we investigated the structure-activity relationships by using the Electron- Topological Method (ETM) for a class of AChE inhibitors related to tacrine (9-amino-1,2,3,4-tetrahydroacridine) and 11 H-Indeno-[1,2-b]-quinolin-10-ylamine that tetracyclic tacrine analogues, a drug currently in use for the treatment of the AD. Molecular fragments being specific for active and inactive compounds were revealed by using ETM. The result of testing showed the high ability of ETM in predicting the activity and inactivity in investigated series.