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The Investigation of Structure-Activity Relationships of Tacrine Analogues: Electronic-Topological Method
The Open Medicinal Chemistry Journal
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6 Aug 2008 •
RESEARCH ARTICLE
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DOI: 10.2174/1874104500802010075
Abstract
In this study we investigated the structure-activity relationships by using the Electron- Topological Method (ETM) for a class of AChE inhibitors related to tacrine (9-amino-1,2,3,4-tetrahydroacridine) and 11 H-Indeno-[1,2-b]-quinolin-10-ylamine that tetracyclic tacrine analogues, a drug currently in use for the treatment of the AD. Molecular fragments being specific for active and inactive compounds were revealed by using ETM. The result of testing showed the high ability of ETM in predicting the activity and inactivity in investigated series.
Keywords: Tacrine analogues, AChE, structure-activity relationships, electronic-topological method.
