RESEARCH ARTICLE
Acridine and Acridinones: Old and New Structures with Antimalarial Activity
Aymé Fernández-Calienes Valdés*
Article Information
Identifiers and Pagination:
Year: 2011Volume: 5
First Page: 11
Last Page: 20
Publisher ID: TOMCJ-5-11
DOI: 10.2174/1874104501105010011
Article History:
Received Date: 30/1/2010Revision Received Date: 6/5/2010
Acceptance Date: 10/7/2010
Electronic publication date: 9/3/2011
Collection year: 2011

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
Abstract
Since emergence of chloroquine-resistant Plasmodium falciparum and reports of parasite resistance to alternative drugs, there has been renewed interest in the antimalarial activity of acridines and their congeners, the acridinones. This article presents literature compilation of natural acridinone alkaloids and synthetic 9-substituted acridines, acridinediones, haloalcoxyacridinones and 10-N-substituted acridinones with antimalarial activity. The review also provides an outlook to antimalarial modes of action of some described compounds.