Acridine and Acridinones: Old and New Structures with Antimalarial Activity



Aymé Fernández-Calienes Valdés*
Departamento de Parasitología, Instituto de Medicina Tropical “Pedro Kourí”, Autopista Novia del Mediodía Km 6 ½, La Lisa, Apartado Postal 601, La Habana, Cuba


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© Aymé Fernández-Calienes Valdés; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Departamento de Parasitología, Instituto de Medicina Tropical “Pedro Kourí”, Autopista Novia del Mediodía Km 6 ½, La Lisa, Apartado Postal 601, La Habana, Cuba; Tel: 53-7-202 06 50; Fax: 53-7-204 6051; E-mail: ayme@ipk.sld.cu


Abstract

Since emergence of chloroquine-resistant Plasmodium falciparum and reports of parasite resistance to alternative drugs, there has been renewed interest in the antimalarial activity of acridines and their congeners, the acridinones. This article presents literature compilation of natural acridinone alkaloids and synthetic 9-substituted acridines, acridinediones, haloalcoxyacridinones and 10-N-substituted acridinones with antimalarial activity. The review also provides an outlook to antimalarial modes of action of some described compounds.

Keywords: Malaria, Plasmodium falciparum, protozoa, acridine, acridinone, acridone, anti-malarial activity.