All published articles of this journal are available on ScienceDirect.

RESEARCH ARTICLE

Thiadiazine Derivatives as Antiprotozoal New Drugs

Julieta Coro Bermelloa Rolando Pérez Piñeirob Lianet Monzote Fidalgoc Hortensia Rodríguez Cabrera, * Open Modal , a Margarita Suárez Navarroa Authors Info & Affiliations
The Open Medicinal Chemistry Journal • 9 Mar 2011 • RESEARCH ARTICLE • DOI: 10.2174/1874104501105010051

Abstract

The 3,5-disubstituted tetrahydro-2H-1,3,5-thiadiazine-2-thione scaffold have found many applications in recent years. This review is aimed at highlighting the most important aspects about these compounds: synthesis, spectroscopic characterization and antiprotozoan activities. How the chemical nature of N-substituents influences the overall activity / cytotoxicity profile will also be discussed.

Keywords: Tetrahydro-2H-1,3,5-thiadiazine-2-thione, antiprotozoan activity.
Fulltext HTML PDF
1800
1801
1802
1803
1804