Thiadiazine Derivatives as Antiprotozoal New Drugs



Julieta Coro Bermelloa, Rolando Pérez Piñeirob, Lianet Monzote Fidalgoc, Hortensia Rodríguez Cabrera*, a, Margarita Suárez Navarroa
a Laboratorio de Síntesis Orgánica. Facultad de Quimica, Universidad de La Habana 10400-Ciudad Habana, Cuba;
b National Institute of Nanotechnology, National Research Council (NINT-NRC), and Department of Chemistry, University of Alberta, 11421 Saskatchewan Drive, Edmonton, AB T6G 2M9, Canada;
c Departamento de Parasitología, Instituto de Medicina Tropical “Pedro Kourí”, Ciudad Habana, Cuba


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© Bermello et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this autor at the Laboratorio de Síntesis Orgánica. Facultad de Quimica, Universidad de La Habana 10400-Ciudad Habana, Cuba; Tel 878-1398; E-mails: horten@fq.uh.cu; hortensia_cu@yahoo.es


Abstract

The 3,5-disubstituted tetrahydro-2H-1,3,5-thiadiazine-2-thione scaffold have found many applications in recent years. This review is aimed at highlighting the most important aspects about these compounds: synthesis, spectroscopic characterization and antiprotozoan activities. How the chemical nature of N-substituents influences the overall activity / cytotoxicity profile will also be discussed.

Keywords: Tetrahydro-2H-1,3,5-thiadiazine-2-thione, antiprotozoan activity.