Thiadiazine Derivatives as Antiprotozoal New Drugs
Julieta Coro Bermelloa, Rolando Pérez Piñeirob, Lianet Monzote Fidalgoc, Hortensia Rodríguez Cabrera*, a, Margarita Suárez Navarroa
Identifiers and Pagination:Year: 2011
First Page: 51
Last Page: 60
Publisher Id: TOMCJ-5-51
Article History:Received Date: 2/2/2010
Revision Received Date: 29/4/2010
Acceptance Date: 15/6/2010
Electronic publication date: 9/3/2011
Collection year: 2011
open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
The 3,5-disubstituted tetrahydro-2H-1,3,5-thiadiazine-2-thione scaffold have found many applications in recent years. This review is aimed at highlighting the most important aspects about these compounds: synthesis, spectroscopic characterization and antiprotozoan activities. How the chemical nature of N-substituents influences the overall activity / cytotoxicity profile will also be discussed.