Thiadiazine Derivatives as Antiprotozoal New Drugs
Julieta Coro Bermelloa
Rolando Pérez Piñeirob
Lianet Monzote Fidalgoc
Hortensia Rodríguez Cabrera, *
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Margarita Suárez Navarroa
Authors Info & Affiliations
, a
Margarita Suárez Navarroa
Authors Info & Affiliations
The Open Medicinal Chemistry Journal
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9 Mar 2011 •
RESEARCH ARTICLE
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DOI: 10.2174/1874104501105010051
Abstract
The 3,5-disubstituted tetrahydro-2H-1,3,5-thiadiazine-2-thione scaffold have found many applications in recent years. This review is aimed at highlighting the most important aspects about these compounds: synthesis, spectroscopic characterization and antiprotozoan activities. How the chemical nature of N-substituents influences the overall activity / cytotoxicity profile will also be discussed.
Keywords: Tetrahydro-2H-1,3,5-thiadiazine-2-thione, antiprotozoan activity.
