RESEARCH ARTICLE


C4-Substituted Isoquinolines: Synthesis and Cytotoxic Action



A Tsotinis*, 1, S Zouroudis1, D Moreau2, C Roussakis2
1 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Athens, Panepistimioupoli-Zografou, 157 71 Athens, Greece
2 ISOMer (Institut des substances et organisms de la mer), Laboratoire de Pharmacologie Marine, Faculté de Pharmacie, Nantes, France


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* Address correspondence to this author at the Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Athens, Panepistimiou-poli-Zografou, 157 71 Athens, Greece; Tel: +30 210 7274812; Fax: +30 210 7274811; E-mail: tsotinis@pharm.uoa.gr


Abstract

A facile synthesis of the C4-substituted isoquinolines 5a-c and 6a-c is described. Commercially available 4-bromoisoquinoline is converted to the α,β-unsaturated esters 8 and 10 on treatment with the appropriate acrylate ester under Heck reaction conditions. The saturated amides 5a-c were obtained from the reaction of ester 9 with the requisite primary amine. Similarly the unsaturated analogues 6a-c were prepared by reacting ester 10 with the appropriate amine. The cytotoxicity of the target molecules was evaluated in two tumour cell lines in vitro. Two compounds, 6b and 6c, showed sufficient activity in the human non-small cell lung cancer line NSCLC-N16-L16 to be worthy of further study.