RESEARCH ARTICLE


Synthesis of Novel 3-Aryl-N-Methyl-1,2,5,6-Tetrahydropyridine Derivatives by Suzuki coupling: As Acetyl Cholinesterase Inhibitors



S.B. Benaka Prasad, Y.C. Sunil Kumar, C.S. Ananda Kumar, C.T Sadashiva, K Vinaya, K.S Rangappa*
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, Mysore-570 006, India


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open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.

* Address correspondence to this author at the University of Mysore, Mana-sagangotri, Mysore, India 570006; Tel: +91- 821-2412191; Fax: +91-821-2412191; E-mail: rangappaks@gmail.com or rangappaks@chemistry.uni-mysore.ac.in


Abstract

Alzheimer’s disease (AD) is a neurodegenerative disorder affecting the central nervous system, which is also associated with progressive loss of memory and cognition. The development of numerous structural classes of compounds with different pharmacological profile could be an evolving, promising therapeutic approach for the treatment of AD. Thus, providing a symptomatic treatment for this disease are cholinomimetics with the pharmacological profile of Acetylcholinesterase (AChE) inhibitors. In view of this, we have synthesized novel 3-aryl-N-methyl-1,2,5,6-tetrahydropyridine derivatives 5a-k by Suzuki coupling and screened the efficacy of these derivatives for their AChE inhibitor activity.

Keywords: Tetrahydropyridine, Suzuki coupling, AChE, Alzheimer's disease.