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Effects on Sperms’ Quality of Selegiline in Aged Rats
Huba Kalász1 , *
Julianna Thuróczy2
Gellért Karvaly3
Lajos Balogh4
István Gyertyán1
Edit Tóth-Molnár5
Ernest Adeghate6
Kornélia Tekes7
Authors Info & Affiliations
Julianna Thuróczy2
Gellért Karvaly3
Lajos Balogh4
István Gyertyán1
Edit Tóth-Molnár5
Ernest Adeghate6
Kornélia Tekes7
Authors Info & Affiliations
The Open Medicinal Chemistry Journal
•
30 Nov 2017 •
RESEARCH ARTICLE
•
DOI: 10.2174/1874104501711010138
Abstract
Background:
Selegiline is used to treat Parkinsonian patients. Other indications of its use have recently been discovered.
Objective:
Scouting special and beneficial side effects of selegiline treatment.
Method:
Two-year old male Wistar rats were daily treated with 0.25 mg/kg of selegiline s.c. (subcutaneous injection). The rats were sacrificed following a four-weeks’ treatment.
Results:
Mass of testes, number of sperms, progressive motility of sperms, and their viability definitely increased.
Conclusion:
Selegiline can successfully be used to stop/counterbalance certain symptoms of aging.
Keywords: Selegiline, Aged-rats, Semen, Dopamine, Testis, Sperm, Testosterone, Cortisol.
