Effects on Sperms’ Quality of Selegiline in Aged Rats

Kalász, Huba; Thuróczy, Julianna; Karvaly, Gellért; Balogh, Lajos; Gyertyán, István; Tóth-Molnár, Edit; Adeghate, Ernest; Tekes, Kornélia

Effects on Sperms’ Quality of Selegiline in Aged Rats

Huba Kalász^{1, *}, Julianna Thuróczy², Gellért Karvaly³, Lajos Balogh⁴, István Gyertyán¹, Edit Tóth-Molnár⁵, Ernest Adeghate⁶, Kornélia Tekes⁷

¹ Department of Pharmacology and Pharmacotherapy, Semmelweis University, 1089 Budapest, Nagyvárad tér 4, Hungary

² Animal Health Center Budafok, H-1221 Budapest, Kossuth Lajos Str. 52. Hungary

³ Department of Laboratory Medicine, Semmelweis University, 1089 Budapest, Nagyvárad tér 4, Hungary

⁴ National “FJC” Research Institute for Radiobiology and Radiohigiene, H-1221 Budapest, Anna Str. 5. Hungary

⁵ Department of Ophthalmology, University of Szeged, 6720 Szeged, Korányi fasor 10- 11, Hungary

⁶ Department of Anatomy, United Arab Emirates University, P.O.Box 17666, Al Ain, United Arab Emirates

⁷ Department of Pharmacodynamics, Semmelweis University, 1089 Budapest, Nagyvárad tér 4, Hungary

Article Information

Identifiers and Pagination:

Year: 2017
Volume: 11
First Page: 138
Last Page: 145
Publisher ID: TOMCJ-11-138
DOI: 10.2174/1874104501711010138

Article History:

Received Date: 14/08/2017
Revision Received Date: 2/11/2017
Acceptance Date: 13/11/2017
Electronic publication date: 30/11/2017
Collection year: 2017

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© 2017 Kalász et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4. 0 International Public License (CC-BY 4. 0), a copy of which is available at: https://creativecommons. org/licenses/by/4. 0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

^* Address correspondence to this author at the Department of Pharmacology and Pharmacotherapy, Semmelweis University, 1089 Budapest, Nagyvárad tér 4, Hungary; Tel: +36309316218; E-mail: drkalasz@gmail.com

Background:

Selegiline is used to treat Parkinsonian patients. Other indications of its use have recently been discovered.

Objective:

Scouting special and beneficial side effects of selegiline treatment.

Method:

Two-year old male Wistar rats were daily treated with 0.25 mg/kg of selegiline s.c. (subcutaneous injection). The rats were sacrificed following a four-weeks’ treatment.

Results:

Mass of testes, number of sperms, progressive motility of sperms, and their viability definitely increased.

Conclusion:

Selegiline can successfully be used to stop/counterbalance certain symptoms of aging.

Keywords: Selegiline, Aged-rats, Semen, Dopamine, Testis, Sperm, Testosterone, Cortisol.

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RESEARCH ARTICLE

Effects on Sperms’ Quality of Selegiline in Aged Rats

Article Information

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Abstract

Background:

Objective:

Method:

Results:

Conclusion:

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About the Journal

The Open Medicinal Chemistry Journal

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Total Views/Downloads: 396,520

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