Effects on Sperms’ Quality of Selegiline in Aged Rats



Huba Kalász1, *, Julianna Thuróczy2, Gellért Karvaly3, Lajos Balogh4, István Gyertyán1, Edit Tóth-Molnár5, Ernest Adeghate6, Kornélia Tekes7
1 Department of Pharmacology and Pharmacotherapy, Semmelweis University, 1089 Budapest, Nagyvárad tér 4, Hungary
2 Animal Health Center Budafok, H-1221 Budapest, Kossuth Lajos Str. 52. Hungary
3 Department of Laboratory Medicine, Semmelweis University, 1089 Budapest, Nagyvárad tér 4, Hungary
4 National “FJC” Research Institute for Radiobiology and Radiohigiene, H-1221 Budapest, Anna Str. 5. Hungary
5 Department of Ophthalmology, University of Szeged, 6720 Szeged, Korányi fasor 10- 11, Hungary
6 Department of Anatomy, United Arab Emirates University, P.O.Box 17666, Al Ain, United Arab Emirates
7 Department of Pharmacodynamics, Semmelweis University, 1089 Budapest, Nagyvárad tér 4, Hungary


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© 2017 Kalász et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4. 0 International Public License (CC-BY 4. 0), a copy of which is available at: https://creativecommons. org/licenses/by/4. 0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Pharmacology and Pharmacotherapy, Semmelweis University, 1089 Budapest, Nagyvárad tér 4, Hungary; Tel: +36309316218; E-mail: drkalasz@gmail.com


Abstract

Background:

Selegiline is used to treat Parkinsonian patients. Other indications of its use have recently been discovered.

Objective:

Scouting special and beneficial side effects of selegiline treatment.

Method:

Two-year old male Wistar rats were daily treated with 0.25 mg/kg of selegiline s.c. (subcutaneous injection). The rats were sacrificed following a four-weeks’ treatment.

Results:

Mass of testes, number of sperms, progressive motility of sperms, and their viability definitely increased.

Conclusion:

Selegiline can successfully be used to stop/counterbalance certain symptoms of aging.

Keywords: Selegiline, Aged-rats, Semen, Dopamine, Testis, Sperm, Testosterone, Cortisol.