Exploration of Adhesion Molecule Expression in Cardiac Muscle of Early Atherosclerosis Dyslipidemic Sprague Dawley Rats
Titin A. Wihastuti1, Fitria N. Aini1, Nurul C. Lutfiana1, Teuku Heriansyah2, *, Nafisatuz Zamrudah1
Identifiers and Pagination:Year: 2018
First Page: 124
Last Page: 129
Publisher Id: TOMCJ-12-124
Article History:Received Date: 30/7/2018
Revision Received Date: 29/9/2018
Acceptance Date: 2/10/2018
Electronic publication date: 24/10/2018
Collection year: 2018
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4. 0 International Public License (CC-BY 4. 0), a copy of which is available at: https://creativecommons. org/licenses/by/4. 0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
This study is aimed to examine the expression of ICAM-1 and VCAM-1 in cardiac tissue of dyslipidemic Sprague Dawley rats.
Eight Sprague Dawley strain rats, with 150-200 gram body weight, were divided into two groups. The control group was fed a standard diet, the positive control group was fed a high-fat diet as our previous study for 8 weeks. The pattern of distribution of ICAM-1 and VCAM-1 in cardiac muscle cell was examined by immunofluorescence and observed with a confocal laser scanning microscope. Lipid profile was also examined at the end of the study.
Independent t-test showed no differences in ICAM-1 and VCAM-1 expression in cardiac muscle of hypercholesterol-diet-fed Sprague Dawley rat compared to control.
The expression of ICAM-1 and VCAM-1 in cardiac muscle did not change after the onset of atherosclerosis.