REVIEW ARTICLE

Chromium Coordination Compounds with Antimicrobial Activity: Synthetic Routes, Structural Characteristics, and Antibacterial Activity

The Open Medicinal Chemistry Journal 29 June 2020 REVIEW ARTICLE DOI: 10.2174/1874104502014010001

Abstract

A major threat to public health worldwide is that the antimicrobial activity of the established drugs is constantly reduced due to the resistance that bacteria develop throughout the years. Some transition metal complexes show higher antibacterial activity against several bacteria compared to those of clinically used antibiotics. Novel classes of molecules provide new challenges and seem promising to solve the crisis that the overuse of antibiotics has led over the last years. This review discusses the challenges of chromium-based metallodrugs as antimicrobial agents. In particular, the synthetic routes, the structural characteristics, as well as the antimicrobial activity of 32 chromium (III) complexes have been presented.

Keywords: Antimicrobial, Chromium, Coordinated compounds, Structure, Transition Metal Complexes.
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