Chromium Coordination Compounds with Antimicrobial Activity: Synthetic Routes, Structural Characteristics, and Antibacterial Activity

Manolis C. Vlasiou1, *, Kyriaki S. Pafiti1
1 Department of Life and Health Sciences, School of Science and Engineering, University of Nicosia, Nicosia, Cyprus

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© 2020 Vlasiou and Pafiti.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Life and Health Sciences, School of Science and Engineering, University of Nicosia, 46 Makedonitissas Avenue, CY- 2417, P.O.Box 24005, CY-1700, Nicosia, Cyprus; Tel: ???????????; E-mail:


A major threat to public health worldwide is that the antimicrobial activity of the established drugs is constantly reduced due to the resistance that bacteria develop throughout the years. Some transition metal complexes show higher antibacterial activity against several bacteria compared to those of clinically used antibiotics. Novel classes of molecules provide new challenges and seem promising to solve the crisis that the overuse of antibiotics has led over the last years. This review discusses the challenges of chromium-based metallodrugs as antimicrobial agents. In particular, the synthetic routes, the structural characteristics, as well as the antimicrobial activity of 32 chromium (III) complexes have been presented.

Keywords: Antimicrobial, Chromium, Coordinated compounds, Structure, Transition Metal Complexes.