REVIEW ARTICLE

Synthesis of Medicinally Important Quinazolines and Their Derivatives: A Review

The Open Medicinal Chemistry Journal 27 Nov 2020 REVIEW ARTICLE DOI: 10.2174/1874104502014010108

Abstract

The study of biodynamic heterosystems has proved to be the most attractive and useful for the development of potential drugs with superior properties and works effectively for the treatment of a variety of diseases, including pandemic ones. Out of the thousand biodynamic heterosystems, the quinazoline heterosystem is one that exhibits wide-ranging biological and pharmacological properties. Synthesis of potential medicinal material is comparatively challenging and needed enough time for clinical trials, testing, permissions for concerned authorities, production and supply. Therefore, researchers usually focused on novel methods incorporated with a high yield of previously approved chemical compounds. This present review article has focused on the synthesis of medicinally important quinazolines and their derivatives, which produce reaction products in less time with high yields, including more attention with eco-friendly green synthesis approaches incorporating multicomponent reactions (MCR), ionic liquids and microwave irradiations.

Keywords: Ionic Liquids, Multicomponent reactions (MCRs), Quinazolines, Quinazolinones, Antimicrobial agents, Green synthesis, benzothiazoloquinazolines.
Fulltext HTML PDF
1800
1801
1802
1803
1804