Synthesis of Medicinally Important Quinazolines and Their Derivatives: A Review

Sulochana Sharma1, Kailash Sharma2, Sakshi Pathak3, Mahendra Kumar3, Praveen Kumar Sharma4, *
1 Department of Chemistry, S.B.R.M. Govt. College, Nagaur, Rajasthan, India
2 Department of Chemistry, Kartik College, Nagaur, Rajasthan, India
3 Department of Chemistry, University of Rajasthan, Jaipur, India
4 School of Chemical Engineering and Physical Science, Lovely Professional University, Phagwara, Punjab, India

© 2020 Sharma et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at Department of Chemistry, Lovely Professional University, Phagwara, Punjab, India-144411; Tel: +919023591664; E-mail:


The study of biodynamic heterosystems has proved to be the most attractive and useful for the development of potential drugs with superior properties and works effectively for the treatment of a variety of diseases, including pandemic ones. Out of the thousand biodynamic heterosystems, the quinazoline heterosystem is one that exhibits wide-ranging biological and pharmacological properties. Synthesis of potential medicinal material is comparatively challenging and needed enough time for clinical trials, testing, permissions for concerned authorities, production and supply. Therefore, researchers usually focused on novel methods incorporated with a high yield of previously approved chemical compounds. This present review article has focused on the synthesis of medicinally important quinazolines and their derivatives, which produce reaction products in less time with high yields, including more attention with eco-friendly green synthesis approaches incorporating multicomponent reactions (MCR), ionic liquids and microwave irradiations.

Keywords: Ionic Liquids, Multicomponent reactions (MCRs), Quinazolines, Quinazolinones, Antimicrobial agents, Green synthesis, benzothiazoloquinazolines.