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Pharmacokinetics of a Mono-pyridinium-mono-aldoxime (K-347), a Potential Antidote in Organophosphate Poisoning
Gellért Karvaly2
Ferenc Szimrók1
Dóra Szabó3
Márton Milánkovits3
András Keglevich1
Jennifer Adeghate4
Ferenc Darvas5
Kamil Kuca6
Kamil Musilek6
Kornélia Tekes7
Authors Info & Affiliations
Abstract
Background:
Our recent work has been treating the pharmacokinetics of pyridinium aldoximes of various structures including their time-dependent distribution in the body of male rats and also the extent of blood-brain-barrier penetration.
Objective:
Our overall aim was to find a proper antidote in organophosphate poisoning with fast elimination.
Methods:
White male Wistar rats were intramuscularly injected with the aqueous solution of 3 µmol of K-347. The animals were sacrificed at different time periods following treatment; various tissues and body fluids were taken and homogenised. The level of K-347 was determined using reversed-phase HPLC. Dose-dependence of tissue level was also determined by using various doses, 3 µmol through 100 µmol of K-347.
Results:
The serum level of K-347 showed a definitely fast decline. K347 did not have any effect on Gram-positive and Gram-negative bacteria that we tested.
Conclusion:
The kinetics of K-347 showed an extremely fast offset, even in comparison with several other pyridinium aldoximes in clinical practice and in developmental stages.
