Molecular Docking and Analysis of Survivin Delta-Ex3 Isoform Protein



Z Ezziane*
Department of Information Technology, Higher Colleges of Technology, Al Ain Women’s College, Al Ain, P.O. Box 17258, United Arab Emirates


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Bentham Science Publishers Ltd

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.

* Address correspondence to this author at the Higher Colleges of Technology, Al Ain Women’s College, Department of IT, P.O. Box 17258, Al Ain, United Arab Emirates; Tel: + 971 3 7095 229; Fax: + 971 3 782 0766; E-mail: zoheir.ezziane@hct.ac.ae


Abstract

This project explores molecular models of Survivin Delta-Ex3, H-Ras, and their binding sites, and generates energy optimized 3D coordinates of docked poses and conformations of the XY2 ligand molecule in the active site of Delta-Ex3. The aim is to propose an effective anti-cancer drug that induces apoptosis and inhibits tumor angiogenesis.