Molecular Docking and Analysis of Survivin Delta-Ex3 Isoform Protein
Identifiers and Pagination:Year: 2008
First Page: 16
Last Page: 20
Publisher Id: TOMCJ-2-16
Article History:Received Date: 21/2/2008
Revision Received Date: 13/3/2008
Acceptance Date: 14/3/2008
Electronic publication date: 27/3/2008
Collection year: 2008
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
This project explores molecular models of Survivin Delta-Ex3, H-Ras, and their binding sites, and generates energy optimized 3D coordinates of docked poses and conformations of the XY2 ligand molecule in the active site of Delta-Ex3. The aim is to propose an effective anti-cancer drug that induces apoptosis and inhibits tumor angiogenesis.