Microwave-Assisted Syntheses of Amino Acid Ester Substituted Benzoic Acid Amides: Potential Inhibitors of Human CD81-Receptor HCV-E2 In-teraction
Marcel Holzer, Sigrid Ziegler, Bernd Kronenberger, Christian D Klein , Rolf W Hartmann;*
Identifiers and Pagination:Year: 2008
First Page: 21
Last Page: 25
Publisher Id: TOMCJ-2-21
Article History:Received Date: 14/2/2008
Revision Received Date: 17/3/2008
Acceptance Date: 18/3/2008
Electronic publication date: 15/4/2008
Collection year: 2008
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
Results from our group showed benzyl salicylate to be a moderate inhibitor of the CD81-LEL–HCV-E2 interaction. To increase the biological activity, heterocyclic substituted benzoic acids were coupled to amino acid esters via microwave assisted DCC-reaction. The prepared compounds were tested for their inhibitory potency by means of a fluorescence labeled antibody assay system using HUH7.5 cells.