Cyclobutane-Containing Alkaloids: Origin, Synthesis, and Biological Activities
Anastasia Sergeiko1, Vladimir V Poroikov1, Lumir O Hanuš2, Valery M Dembitsky*, 2
Identifiers and Pagination:Year: 2008
First Page: 26
Last Page: 37
Publisher ID: TOMCJ-2-26
Article History:Received Date: 6/3/2008
Revision Received Date: 18/3/2008
Acceptance Date: 18/3/2008
Electronic publication date: 15/4/2008
Collection year: 2008
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
Present review describes research on novel natural cyclobutane-containing alkaloids isolated from terrestrial and marine species. More than 60 biological active compounds have been confirmed to have antimicrobial, antibacterial, antitumor, and other activities. The structures, synthesis, origins, and biological activities of a selection of cyclobutane-containing alkaloids are reviewed. With the computer program PASS some additional biological activities are also predicted, which point toward new possible applications of these compounds. This review emphasizes the role of cyclobutane-containing alkaloids as an important source of leads for drug discovery.