RESEARCH ARTICLE


Cyclobutane-Containing Alkaloids: Origin, Synthesis, and Biological Activities



Anastasia Sergeiko1, Vladimir V Poroikov1, Lumir O Hanuš2, Valery M Dembitsky*, 2
1 Institute of Biomedical Chemistry, Russian Academy of the Medical Sciences, Moscow 119121, Russia
2 Department of Medicinal Chemistry and Natural Products, School of Pharmacy, P.O. Box 12065, The Hebrew Univer-sity of Jerusalem, Jerusalem 91120, Israel


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© Sergeikoet al.; Licensee Bentham Open.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.

* Address correspondence to this author at the Department of Medicinal Chemistry and Natural Products, School of Pharmacy, P.O. Box 12065, The Hebrew University of Jerusalem, Jerusalem 91120, Israel; Tel/Fax: +972-2-590-2947; E-mail: dvalery@cc.huji.ac.il


Abstract

Present review describes research on novel natural cyclobutane-containing alkaloids isolated from terrestrial and marine species. More than 60 biological active compounds have been confirmed to have antimicrobial, antibacterial, antitumor, and other activities. The structures, synthesis, origins, and biological activities of a selection of cyclobutane-containing alkaloids are reviewed. With the computer program PASS some additional biological activities are also predicted, which point toward new possible applications of these compounds. This review emphasizes the role of cyclobutane-containing alkaloids as an important source of leads for drug discovery.

Keywords: Alkaloids, cyclobutane-containing, anticancer, antibacterial, synthesis, activities, terrestrial, marine.