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RESEARCH ARTICLE

Cyclobutane-Containing Alkaloids: Origin, Synthesis, and Biological Activities

Anastasia Sergeiko1 Vladimir V Poroikov1 Lumir O Hanuš2 Valery M Dembitsky, * Open Modal , 2 Authors Info & Affiliations
The Open Medicinal Chemistry Journal • 15 Apr 2008 • RESEARCH ARTICLE • DOI: 10.2174/1874104500802010026

Abstract

Present review describes research on novel natural cyclobutane-containing alkaloids isolated from terrestrial and marine species. More than 60 biological active compounds have been confirmed to have antimicrobial, antibacterial, antitumor, and other activities. The structures, synthesis, origins, and biological activities of a selection of cyclobutane-containing alkaloids are reviewed. With the computer program PASS some additional biological activities are also predicted, which point toward new possible applications of these compounds. This review emphasizes the role of cyclobutane-containing alkaloids as an important source of leads for drug discovery.

Keywords: Alkaloids, cyclobutane-containing, anticancer, antibacterial, synthesis, activities, terrestrial, marine.
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