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Cell Engineering and Molecular Pharming for Biopharmaceuticals
The Open Medicinal Chemistry Journal
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14 May 2008 •
RESEARCH ARTICLE
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DOI: 10.2174/1874104500802010049
Abstract
Biopharmaceuticals are often produced by recombinant E. coli or mammalian cell lines. This is usually achieved by the introduction of a gene or cDNA coding for the protein of interest into a well-characterized strain of producer cells. Naturally, each recombinant production system has its own unique advantages and disadvantages. This paper examines the current practices, developments, and future trends in the production of biopharmaceuticals. Platform technologies for rapid screening and analyses of biosystems are reviewed. Strategies to improve productivity via metabolic and integrated engineering are also highlighted.
