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Basic Aspects of the Pharmacodynamics of Tolperisone, A Widely Applicable Centrally Acting Muscle Relaxant
The Open Medicinal Chemistry Journal
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11 July 2014 •
RESEARCH ARTICLE
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DOI: 10.2174/1874104501408010017
Abstract
Tolperisone (2-methyl-1-(4-methylphenyl)-3-piperidin-1-ylpropan-1-one hydro-chloride) was introduced in the clinical practice more than forty years ago and is still evaluated as a widely applicable compound in pathologically elevated skeletal muscle tone (spasticity) and related pains of different origin. In the present review, basic pharmacodynamic effects measured on whole animals, analyses of its actions on cell and tissue preparations and molecular mechanism of action on sodium and calcium channels are summarized as recently significantly new data were reported.
Keywords: Centrally acting muscle relaxant, inhibition of monosynaptic reflexes, N-type calcium channel blocking, sodium channels, spasticity, Tolperisone.
