Basic Aspects of the Pharmacodynamics of Tolperisone, A Widely Applicable Centrally Acting Muscle Relaxant

Kornelia Tekes*
Department of Pharmacodynamics, Semmelweis University, Budapest, Hungary

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© Kornelia Tekes; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Pharmacodynamics, Semmelweis University, Nagyvarad ter 4. H-1089 Budapest, Hungary; Tel: +36-1-210-29-30/56108; Fax: +36-1-210-44-00; E-mail:


Tolperisone (2-methyl-1-(4-methylphenyl)-3-piperidin-1-ylpropan-1-one hydro-chloride) was introduced in the clinical practice more than forty years ago and is still evaluated as a widely applicable compound in pathologically elevated skeletal muscle tone (spasticity) and related pains of different origin. In the present review, basic pharmacodynamic effects measured on whole animals, analyses of its actions on cell and tissue preparations and molecular mechanism of action on sodium and calcium channels are summarized as recently significantly new data were reported.

Keywords: Centrally acting muscle relaxant, inhibition of monosynaptic reflexes, N-type calcium channel blocking, sodium channels, spasticity, Tolperisone.