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RESEARCH ARTICLE

Microwave-Assisted Syntheses of Amino Acid Ester Substituted Benzoic Acid Amides: Potential Inhibitors of Human CD81-Receptor HCV-E2 In-teraction

Marcel Holzer Sigrid Ziegler Bernd Kronenberger Christian D Klein Rolf W Hartmann, ;* Open Modal Authors Info & Affiliations
The Open Medicinal Chemistry Journal • 15 Apr 2008 • RESEARCH ARTICLE • DOI: 10.2174/1874104500802010021

Abstract

Results from our group showed benzyl salicylate to be a moderate inhibitor of the CD81-LEL–HCV-E2 interaction. To increase the biological activity, heterocyclic substituted benzoic acids were coupled to amino acid esters via microwave assisted DCC-reaction. The prepared compounds were tested for their inhibitory potency by means of a fluorescence labeled antibody assay system using HUH7.5 cells.

Keywords: Hepatitis C virus, microwave assisted amide syntheses, CD81-receptor, large extracellular loop, benzyl salicylate, protein-protein interaction.
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